zurück Home	Rezeptor-TK-Familien (TK)
allgemeines
Funktion
RTK class I	EGF receptor family, ErbB family	ErbB-1 (EGFR), ErbB-2 (HER2), ErbB-3 (HER3), ErbB-4 (HER4)
RTK class II	Insulin receptor family	Insulin-Rezeptor, ALK, ROS1
RTK class III	PDGF receptor family	Platelet-Derived Growth Factor Receptor, PDGF
RTK class IV	FGF receptor family	Fibroblast Growth Factor Receptor
RTK class V	VEGF receptors family	Vascular Endothelial Growth Factor, VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3
RTK class VI	HGF receptor family	Hepatocyte Growth Factor Receptor (HGFR) = c-Met
RTK class VII	Trk receptor family	TrkA bindet Nerve Growth Factor (NGF). TrkB bindet Brain-Derived Neurotrophic Factor (BDNF) und Neurotropin (NT)-4. TrkC bindet NT-3
RTK class VIII	Eph receptor family	Ephrin receptors, EphAs, EphBs
RTK class IX	AXL receptor family	Axl: CML-assoziiertes Oncogen
RTK class X	LTK receptor family	Leukocyten Receptor TK
RTK class XI	TIE receptor family	Angiopoietin Receptoren: TIE-1, TIE-2 binden Ang1, Ang2, Ang3, Ang4
RTK class XII	ROR receptor family	Receptor tyrosine kinase-like Orphan Receptors. Regulieren Skelett- und neuronale Entwicklung.
RTK class XIII	DDR receptor family	Discoidin Domain receptor family, DDR1 = CD167a, DDR2
RTK class XIV	RET receptor family	Binden Glial Cell Line-Derived Neurotrophic Factoren (GDNF)
RTK class XV	KLG receptor family	PTK7, Tyrosine-Protein Kinase-Like 7: Kontext-abhängiger Schalter für den Wnt - Signalweg.
RTK class XVI	RYK receptor family	RYK, Related to Receptor Tyrosine Kinase. Funktion unklar.
RTK class XVII	MuSK receptor family	Muscle-Specific Kinase. Durch Agrin aktiviert. Bildung der neuromuskulären Verbindung.
Quellen

Impressum                               Zuletzt geändert am 03.07.2023 18:19