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Praevention

Allgemeines

Screening

Stuhltest Endoskopie

ASS

ASS Einnahme vermindert das Risiko von colorektalen Malignomen (1-6).
ASS Einnahme verlängert die Überlebenszeit nach Colonkarzinom bei PIK3CA - Mutation, aber nicht bei PIK3CA - Wildtyp(7).

Quellen

1.) Sandler RS, et al.:
A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer.
N Engl J Med 348(2003):883-90

2.) Burn J, et al.:
Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial.
Lancet 378(2011):2081-7

3.) Algra AM, Rothwell PM:
Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials.
Lancet Oncol 13(2012):518-27

4.) Din FV, et al.:
Effect of aspirin and NSAIDs on risk and survival from colorectal cancer.
Gut 59(2010):1670-9

5.) Dubé C, et al.:
The use of aspirin for primary prevention of colorectal cancer: a systematic review prepared for the U.S. Preventive Services Task Force.
Ann Intern Med 146(2007):365-75

6.) Flossmann E, Rothwell PM.:
Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies.
Lancet 369(2007):1603-13

7.) Liao X, et al.:
Aspirin Use, Tumor PIK3CA Mutation, and Colorectal-Cancer Survival.
N Engl J Med 367(2012):1596-606

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Impressum.................................................................................... Zuletzt geändert am 27.10.2012 5:41