postoperative Chemotherapie des NSCLC
Allgemeines
Platin-haltige Therapie
| Studie | Patienten | Stadium | Population | Stage IA | Stage IB | Stage 11 | Stage IIIA | Bemerkungen |
| IALT (2) | 1.867 | I-III | Global | NS | NS | NS | signigikant besser | |
| NCIC JBR.10 (4) | 482 | IB-II | Nord Amerika | NT | NS | signigikant besser | NT | |
| ANITA (3) | 840 | IB—IIIA | Europa, Amerika, Süd Afrika | NT | NS | signigikant besser | signigikant besser | |
| ALPI (7) | 1.209 | I—IIIA | Europa | NS | NS | NS | NS | |
| Big Lung Trial (6) | 381 | I—IIIA | UK | NS | NS | NS | NS | |
| CALGB 9633 (8) | 344 | IB | USA | NT | NS | NT | NT | |
| LACE (5) | 4.584 | I-III | Global | NS | NS | signigikant besser | signigikant besser | Metaanalyse |
Quellen
Phase 1 study of vinorelbin and carboplatin in advanced non-small cell lung cancer.
Lung Cancer 12(1995):247-257
2.) Arriagada R, Bergman B, Dunant A et al.:
International Adjuvant Lung Cancer Trial Collaborative Group. Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer.
N Engl J Med 2004;350:351-360.
3.) Douillard JY, Rosell R, De Lena M et al.:
Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB-IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): A randomised controlled trial.
Lancet Oncol 2006;7:719-727.
4.) Winton T, Livingston R, Johnson D et al.:
National Cancer Institute of Canada Clinical Trials Group; National Cancer Institute of the United States Intergroup JBR.10 Trial Investigators. Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer.
N Engl J Med 2005;352:2589-2597.
5.) Pignon JP, Tribodet H, Scagliotti GV et al.:
LACE Collaborative Group. Lung Adjuvant Cisplatin Evaluation: A pooled analysis by the LACE Collaborative Group.
J Clin Oncol 2008;26:3552-3559.
6.) Waller D, Peake MD, Stephens RJ et al.:
Chemotherapy for patients wich non-small cell lung cancer: The surgical setting of the Big Lung Trial.
Eur J Cardiothorac Surg 2004;26:173-182.
7.) Scagliotti GV, Fossati R, Torri V et al.:
Adjuvant Lung Project Italy/European Organisation for Research Treatment of Cancer-Lung Cancer Cooperative Group Investigators. Randomized study of adjuvant chemotherapy for completely resected stage 1, 11, or IIIA nonsmall-cell lung cancer.
J Natl Cancer Inst 2003;95:14531461.
8.)Strauss GM, et al.:
Adjuvant paclitaxel plus carboplatin compared with observation in stage IB non-small-cell lung cancer: CALGB 9633 with the Cancer and Leukemia Group B, Radiation Therapy Oncology Group, and North Central Cancer Treatment Group Study Groups.
J Clin Oncol 2008;26:5043-51. doi: 10.1200/JCO.2008.16.4855.
