| extended field RT, Paclitaxel - Cisplatin | GOG 9804 (3) | Phase I/II study of extended field radiation therapy with concomitant paclitaxel and cisplatin chemotherapy in patients with cervical carcinoma metastatic to the para-aortic lymph nodes o PMID 19010522 (2009) | |
| extended field RT, Cisplatin | RTOG 0116 (2) | Primäre Therapie bei aortalen Metastasen:Extended-field RT + AL + Cisplatin | 0116 A Two Part Phase I/II Study of Extended Field External Irradiation and Intracavitary Brachytherapy Combined with Chemotherapy and Amifostine in Carcinoma of the Cervix with Positive Para-Aortic or High Common Iliac Lymph Nodes Terminated I/II |
| FU + Cisplatin v. Hydroxyurea | GOG 85 | ||
| Hydroxyurea v. Cisplatin v. FU + Cisplatin + Hydroxyurea | GOG 120 | Nachfolgestudie der GOG 85 | |
| +- Epo | GOG 191 | Cervix - Stage III | Chemo-RT +/- EPO o PMID 18037478 (2008): Stopped prematurely due to concerns about thromboembolism GOG-191 Phase III trial to evaluate the efficacy of maintaining hemoglobin levels above 12.0 g/dL with erythropoietin vs above 10.0 g/dL without erythropoietin in anemic patients receiving radiation and cisplatin for cervical cancer. Gynecol Oncol 108(2): 317-25, 2008. Here Thomas G, Ali S, Hoebers FJ, Darcy KM, Rodgers WH, Patel M, Abulafia O, Lucci JA, Begg AC |
| Cisplatin v 5-FU | GOG 165 | Cisplatin ist einer Dauerinfusion mit 5-FU in der primär kombinierten Radiochemotherapie des inoperablen Zervixkarzinoms überlegen. | |
| FU + Cisplatin v. Hydroxyurea | GOG 85 | ||
| FU + Cisplatin + Celebrix | RTOG 01-28 | 0128 A Phase I/II Study of Cox-2 Inhibitor, Celebrex™ (Celecoxib) And Chemo-Radiation In Patients With Locally Advanced Cervical Cancer | Terminated Phase I/II |
| weekly Cisplatin +- Tirapazamin | GOG-219 | A Gynecologic Oncology Group phase III randomized trial of weekly cisplatin and radiation versus cisplatin and tirapazamine and radiation in stage IB2, IIA, IIIB and IVA cervical carcinoma limited to the pelvis. Gynecol Oncol 125(s1) (SGO #2): S3, 2012. (Abstract) DiSilvestro PA, Ali S, Craighead PS, Lucci JA, Lee YC, Cohn D, Spirtos NM, Tewari K, Muller C, Steinhoff | |
| Radiochemotherapie +- Chemotherapie | ANZGOG 0902/GOG-0274/RTOG 1174, OUTBACK Trial | A Phase III Trial of Adjuvant Chemotherapy as Primary Treatment for Locally Advanced Cervical Cancer Compared to Chemoradiation Alone Open III | |
| primäre RT + Cisplatin + Bevacizumab | RTOG 04-17 | 0417 A Phase II Study of Bevacizumab in Combination with Definitive Radiotherapy and Cisplatin Chemotherapy in Untreated Patients with Locally Advanced Cervical Carcinoma | Closed, Phase II |
| primär kombinierte Bestrahlung + Cisplatin | Zulani-Brasilien | ||
| Radikaler Hysterektomie mit Radio-Chemotherapie versus primärer Radio-Chemotherapie | ARO 2013-3 | Zervix Stadium IB2 und IIB: Randomisierter Vergleich zwischen Radikaler Hysterektomie mit Radio-Chemotherapie versus primärer Radio-Chemotherapie. Phase III. Marnitz, Köln |
| INTERLACE | Short-course induction chemotherapy followed by chemoradiotherapy significantly improves survival of patients with locally advanced cervical cancer |
| RTOG 0724/GOG-0724 | phase III randomized study of concurrent chemotherapy and pelvic radiation therapy with or without adjuvant chemotherapy in high-risk patients with early-stage cervical carcinoma following radical hysterectomy | open, Phase III |
| RTOG1171 - GOG0263 | 1171 GOG-0263/Endorsed Study: "Randomized Phase III Clinical Trial of Adjuvant Radiation Versus Chemoradiation in Intermediate Risk, Stage I/IIA Cervical Cancer Treated With Initial Radical Hysterectomy and Pelvic Lymphadenectomy " Open III |
| EORTC55954/NSGO/COSA/MRC intergroup | A randomized phase III study of chemotherapy and radiotherapy versus radiotherapy alone as adjuvant treatment to patients with node positive stages Ib or IIa cervix cancer (EO ORTC/NSGO/COSA/MRC intergroup trial) |
Longterm follow-up of RTOG 92-10: cervical cancer with positive para-aortic lymph nodes.
IJROBP 51(2001):982–987
2.) Small J, Winter K, Levenback C, et al.:
Extended-field irradiation and intracavitary brachytherapy combined with cisplatin chemotherapy for cervical cancer with positive para-aortic or high common iliac lymph nodes: Results of ARM 1 of RTOG 0116.
IJROBP 68(2007):1081–1087
3.) Walker JL, Morrison A, DiSilvestro P, Von GV:
A phase I/II study of extended field radiation therapy with concomitant paclitaxel and cisplatin chemotherapy in patients with cervical carcinoma metastatic to the para-aortic lymph nodes: A Gynecologic Oncology Group study.
Gynecol Oncol 112(2009):78–84
