zurück Home postoperative Radiotherapie des DCIS
allgemeines In randomisierten Studien wurde nachgewiesen, dass eine Bestrahlung nach brusterhaltender Operation das Rezidivrisiko eines DCIS senkt.
Studien
Studie Zeit Pat. invasive Rezidive DCIS-Rezidive
ohne RT mit RTohne RT mit RT
NSABP 17 1985-1990 818 13 4 13 8
EORTC 1083 1986-1996 1010 13 8 14 7
UK DCIS 1987-1999 1067 6 3 7 3
Summe   2895 32 15 34 18
Quellen

1.) Ringberg A, Nordgren H, Thorstensson S, Idvall I, Garmo H, Granstrand B, Arnesson LG, Sandelin K, Wallgren A, Anderson H, Emdin S, Holmberg L:
Histopathological risk factors for ipsilateral breast events after breast conserving treatment for ductal carcinoma in situ of the breast--results from the Swedish randomised trial.
Eur J Cancer. 2007 Jan;43(2):291-8.
Department of Plastic Surgery, Malmö University Hospital, Malmö, Sweden.

2.) Wai, E. S. et al.:
Effect of radiotherapy boost and hypofractionation on outcomes in ductal carcinoma in situ.
Cancer 2011,117(1):54-62

3.) Wapnir IL, Dignam JJ, Fisher B, et al:
Long-term outcomes of invasive ipsilateral breast tumor recurrences after lumpectomy in NSABP B-17 and B-24 randomized clinical trials for DCIS.
J Natl Cancer Inst 2011;103:478-488,

4.) Wärnberg F, Garmo H, Emdin S, et al:
Effect of radiotherapy after breast conserving surgery for ductal carcinoma in situ: 20 years follow-up in the randomized SweDCIS Trial.
J Clin Oncol 2014;32:3613-3618

5.) Donker M, Liti `ere S, Werutsky G, et al:
Breast-conserving treatment with or without radiotherapy in ductal carcinoma in situ:
15-year recurrence rates and outcome after a recurrence, from the EORTC 10853 randomized phase III trial.
J Clin Oncol 2013;31:4054-4059

6.) Cuzick J, Sestak I, Pinder SE, et al:
Effect of tamoxifen and radiotherapy in women with locally excised ductal carcinoma in situ:
Long-term results from the UK/ANZ DCIS trial.
Lancet Oncol 2011;12:21-29

7.) McCormick B, Winter K, Hudis C, et al:
RTOG 9804: A prospective randomized trial for good-risk ductal carcinoma in situ comparing radiotherapy with observation.
J Clin Oncol 2015;33:709-715

8.) Silverstein MJ, Lagios MD:
Choosing treatment for patients with ductal carcinoma in situ: Fine tuning the University of Southern California/Van Nuys Prognostic Index.
J Natl Cancer Inst Monogr 2010:193-1962010

9.) Silverstein MJ, Lagios MD, Craig PH, et al:
A prognostic index for ductal carcinoma in situ of the breast.
Cancer 1996;77:2267-2274

10.) Rudloff U, Jacks LM, Goldberg JI, et al:
Nomogram for predicting the risk of local recurrence after breast conserving surgery for ductal carcinoma in situ.
J Clin Oncol 2010;28:3762-3769

11.) MacAusland SG, Hepel JT, Chong FK, et al:
An attempt to independently verify the utility of the Van Nuys Prognostic Index for ductal carcinoma in situ.
Cancer 2007 ;110:2648-2653

12.) Yi M, Meric-Bernstam F, Kuerer HM, et al:
Evaluation of a breast cancer nomogram for predicting risk of ipsilateral breast tumor recurrences in patients with ductal carcinoma in situ after local excision.
J Clin Oncol 2012;30:600-607
13.) Wong JS, Chen Y-H, Gadd MA, et al: Eight-year update of a prospective study of wide excision alone for small low- or intermediate-grade ductal carcinoma in situ (DCIS). Breast Cancer Res Treat 2014;143:343-350

Impressum .....................................................................................Zuletzt geändert am 27.09.2012 15:00