zurück Home Rezeptorstatus von Metastasen des Mamma - Karzinoms
allgemeines Bei der Behandlung geht man davon aus, dass Rezidive und Metastasen den gleichen Rezeptorstatus haben, wie der Primärtumor. Im Einzelfall gibt es auch Abweichungen. Literaturzusammenstellung (1)
Östrogen - Rezeptor von Metastasen Primärtumor Östrogen - Rezeptor positiv
Autor Jahr Metastase/Rezidiv Östrogen-Rezeptor
positiv negativ
Hoehn (6) 1979 13 0
Brennan (7) 1979 3 2
Hull (8) 1983 81 23
Holdaway (9) 1983 3 6
Raemaekers (10) 1984 35 8
Nomura (11) 1985 17 10
Kamby (12) 1989 16 24
Spataro (13) 1992 185 76
Li (14) 1994 50 13
Kuukasjärvi (15) 1996 23 12
Shimizu (16) 2000 5 5
Sekido (17) 2003 27 6
Lower (18) 2005 76 39
Gutierrez (19) 2005 24 5
Gomez-Fernandez (20) 2008 150 9
Wu (21) 2008 4 2
Broom (22) 2009 45 6
Thompson (4) 2010 98 11
Idirisinghe (23) 2010 62 12
Hoefnagel (24) 2010 130 17
Gong (2) 2011 147 10
Bogina (25) 2011 103 8
Curigliano (26) 2011 175 22
Sari (27) 2011 33 16
Nishimura (28) 2011 54 8
Chang (29) 2011 18 8
Amir (5) 2012 58 11
Jensen (30) 2012 85 10
Montagna (31) 2012 187 18
Duchnowska (32) 2012 29 22
Lindstrom (33) 2012 216 113
Ibrahim (34) 2013 76 11
Dieci (35) 2013 81 13
Aurilio (36) 2013 81 19
Curtit (37) 2013 164 29
de Duenas (3) 2014 108 16
Summe   2662 620
Prozent   81,1% 18,9%

Metastasen / Rezidive Östrogen-Rezeptor positiver Tumoren sind zu 4/5 ebenfalls Rezeptor positiv in 1/5 Rezeptor negativ.
Primärtumor Östrogen - Rezeptor negativ
Autor Jahr Metastase/Rezidiv Östrogen-Rezeptor
positiv negativ
Hoehn (6) 1979 7 17
Brennan (7) 1979 5 17
Hull (8) 1983 12 51
Holdaway (9) 1983 9 10
Raemaekers (10) 1984 6 26
Nomura (11) 1985 0 15
Kamby (12) 1989 2 50
Spataro (13) 1992 46 94
Li (14) 1994 11 9
Kuukasjärvi (15) 1996 0 15
Shimizu (16) 2000 0 10
Sekido (17) 2003 1 10
Lower (18) 2005 21 64
Gutierrez (19) 2005 0 10
Gomez-Fernandez (20) 2008 0 119
Wu (21) 2008 0 4
Broom (22) 2009 5 6
Thompson (4) 2010 3 25
Idirisinghe (23) 2010 7 36
Hoefnagel (24) 2010 7 79
Gong (2) 2011 7 63
Bogina (25) 2011 1 28
Curigliano (26) 2011 15 43
Sari (27) 2011 11 15
Nishimura (28) 2011 2 33
Chang (29) 2011 9 21
Amir (5) 2012 4 21
Jensen (30) 2012 4 19
Montagna (31) 2012 7 70
Duchnowska (32) 2012 13 56
Lindstrom (33) 2012 36 94
Ibrahim (34) 2013 8 21
Dieci (35) 2013 3 22
Aurilio (36) 2013 3 4
Curtit (37) 2013 11 31
de Duenas (3) 2014 5 38
Summe   281 1212
Prozent   18,8% 81,2%

Metatasen / Rezidive Östrogen-Rezeptor negativer Tumoren sind zu 4/5 ebenfalls Rezeptor negativ in 1/5 Rezeptor positiv.
Progesteron - Rezeptor von Metastasen Primärtumor Progesteron - Rezeptor positiv
Autor Jahr Metastase/Rezidiv Progesteron-Rezeptor
positiv negativ
Holdaway (9) 1983 1 4
Raemaekers (10) 1984 13 10
Li (14) 1994 10 8
Kuukasjärvi (15) 1996 18 12
Shimizu (16) 2000 6 6
Sekido (17) 2003 16 8
Lower (18) 2005 34 59
Wu (21) 2008 3 2
Broom (22) 2009 24 22
Thompson (4) 2010 63 22
Idirisinghe (23) 2010 33 37
Hoefnagel (24) 2010 71 58
Bogina (25) 2011 66 25
Curigliano (26) 2011 58 106
Sari (27) 2011 22 26
Nishimura (28) 2011 36 19
Chang (29) 2011 11 10
Amir (5) 2012 12 34
Montagna (31) 2012 112 46
Duchnowska (32) 2012 18 23
Lindstrom (33) 2012 109 142
Ibrahim (34) 2013 24 38
Dieci (35) 2013 36 36
Aurilio (36) 2013 43 43
Curtit (37) 2013 98 52
de Duenas (3) 2014 86 34
Summe   1023 882
Prozent   53,7% 46,3%

Metastasen / Rezidive Progesteron-Rezeptor positiver Tumoren sind nur zur Häfte Rezeptor positiv in knapp der Hälfte Rezeptor negativ.
Primärtumor Progesteron - Rezeptor negativ
Autor Jahr Metastase/Rezidiv Progesteron-Rezeptor
positiv negativ
Holdaway (9) 1983 3 12
Raemaekers (10) 1984 4 23
Li (14) 1994 6 8
Kuukasjärvi (15) 1996 0 20
Shimizu (16) 2000 0 8
Sekido (17) 2003 2 18
Lower (18) 2005 9 71
Wu (21) 2008 0 4
Broom (22) 2009 0 13
Thompson (4) 2010 12 40
Idirisinghe (23) 2010 8 43
Hoefnagel (24) 2010 12 92
Bogina (25) 2011 5 44
Curigliano (26) 2011 18 73
Sari (27) 2011 13 11
Nishimura (28) 2011 6 36
Chang (29) 2011 4 31
Amir (5) 2012 4 44
Montagna (31) 2012 16 105
Duchnowska (32) 2012 11 67
Lindstrom (33) 2012 33 146
Ibrahim (34) 2013 10 43
Dieci (35) 2013 10 36
Aurilio (36) 2013 4 17
Curtit (37) 2013 17 68
de Duenas (3) 2014 13 34
Summe   220 1107
Prozent   16,6% 83,4%

Metastasen / Rezidive Progesteron-Rezeptor negativer Tumoren sind zu 5/6 auch Rezeptor negativ in 1/6 Rezeptor positiv.
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