AML: Studien
Induction therapy comparing standard-dose idarubicin with high-dose daunorubicin
CPX-351 (cytarabine and daunorubicin) liposome for in- jection versus conventional cytarabine plus dau- norubicin in older patients with newly diagnosed secondary acute myeloid leukemia.
High-dose cytarabine and timed-sequential chemotherapy as consolidation for younger adults
AML-BMF87, AML-BMF93, AML-BMF98, AML-BMF98, AML-BMF04
Ab 1978 Erfassung aller AML von Kindern und Jugendlichen von 60 Kliniken in der BRD, Österreich, Schweiz und Tschechei
Cytarabine Dose of 36 g/m2 Compared With 12 g/m2 Within First Consolidation
Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation.
Quellen
1.) Büchner T, Berdel WE, Haferlach C, Haferlach T, Schnittger S, Müller-Tidow C,
et al.:
Age-related risk profile and chemotherapy dose response in acute myeloid
leukemia: a study by the German Acute Myeloid Leukemia Cooperative Group.
J Clin Oncol 2009; 27: 61–9
2.) Löwenberg B, Zittoun R, Kerkhofs H, et al.:
On the value of intensive remission-induction chemotherapy in elderly patients of 65+ years with acute myeloid leukemia:
a randomized phase III study of the European Organization for Research and Treatment of Cancer Leukemia Group.
J Clin Oncol 1989; 7: 1268–74.
3.) Ziogas DC, Voulgarelis M, Zintzaras E:
A Network Meta-analysis of Randomized Controlled Trials of Induction Treatments in Acute Myeloid Leukemia in the Elderly.
Clin Ther 2011; 33: 254–79.
4.) Büchner T, Urbanitz D, Hiddemann W, et al.:
Intensified induction and consolidation with or without maintenance chemotherapy for acute myeloid leukemia (AML): two multicenter
studies of the German AML Cooperative Group.
J Clin Oncol 1985; 3: 1583–9
5.) Ohtake S, Miyawaki S, Fujita H, et al.:
Randomized study of induction therapy comparing standard-dose idarubicin with high-dose daunorubicin in adult patients with
previously untreated acute myeloid leukemia: the JALSG AML201 Study.
Blood 2011; 117: 2358–65
6.) Thomas X, Elhamri M, Raffoux E, et al.:
Comparison of high-dose cytarabine and timed-sequential chemotherapy as consolidation for younger adults
with AML in first remission: the ALFA-9802 study.
Blood 2011; 118: 1754–62
7.) Schaich M, Röllig C, Soucek S, et al.:
Cytarabine Dose of 36 g/m2 Compared With 12 g/m2 Within First Consolidation in Acute Myeloid Leukemia: Results of
Patients Enrolled Onto the Prospective Randomized AML96 Study.
J Clin Oncol 2011; 29: 2696–702
8.) Stone RM, et al.:
Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation.
N Engl J Med 2017;377:454-64
DOI: 10.1056/NEJMoa1614359
