zurück Home

Anal - Karzinom: Studien

4-armige Studie: Induktionschemotherapie oder Hochdosisboost verbessern das Ergebnis nicht signifikant.

Phase II evaluation of dose-painted IMRT in combination with 5-Fluorouracil and Mitomycin-C for reduction of acute morbidity in carcinoma of the anal canal

Radiation with continuous infusion of fluorouracil plus cisplatin has been evaluated, as seen in the RTOG-9811 trial. [14]

The optimal dose of radiation with concurrent chemotherapy to optimize local control and minimize sphincter toxic effects has been studied in the RTOG-9208 trial, for example, and appears to be in the 45 Gy to 60 Gy range. (8)

Chemotherapy concurrent with lower-dose radiation therapy as evidenced in the RTOG-8314 trial, for example, has a 5-year survival rate in excess of 70% with low levels of acute and chronic morbidity, and few patients req

1.) Leichman L, Nigro N, Vaitkevicius VK, et al.:
Cancer of the anal canal. Model for preoperative adjuvant combined modality therapy.
Am J Med 78(1985):211-5

2.) Sischy B:
The use of radiation therapy combined with chemotherapy in the management of squamous cell carcinoma of the anus and marginally resectable adenocarcinoma of the rectum.
Int J Radiat Oncol Biol Phys 11(1985): 1587-93

3.) Sischy B, Doggett RL, Krall JM, et al.:
Definitive irradiation and chemotherapy for radiosensitization in management of anal carcinoma: interim report on Radiation Therapy Oncology Group study no. 8314.
J Natl Cancer Inst 81(1989): 850-6

4.) Cummings BJ:
Anal cancer.
Int J Radiat Oncol Biol Phys 19(1990): 1309-15

5.) Zucali R, Doci R, Bombelli L:
Combined chemotherapy--radiotherapy of anal cancer.
Int J Radiat Oncol Biol Phys 19 (1990):1221-3

6.) Fuchshuber PR, Rodriguez-Bigas M, Weber T, et al.:
Anal canal and perianal epidermoid cancers.
J Am Coll Surg 185 (1997): 494-505

7.) Fung CY, Willett CG, Efird JT, et al.:
Chemoradiotherapy for anal carcinoma: what is the optimal radiation dose?
Radiat Oncol Investig 2(1994): 152-6

8.) John M, Pajak T, Flam M, et al.:
Dose Escalation in Chemoradiation for Anal Cancer: Preliminary Results of RTOG 92-08.
Cancer J Sci Am 2 (1996): 205-11

9.) Flam M, John M, Pajak TF, et al.:
Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study.
J Clin Oncol 14 (1996):2527-39