- tiefe stromale Invasion (> 1/3)
- Lymphangiosis carcinomatosa
- Tumor 4cm oder mehr
| Kriterium | postoperative Bestrahlung | keine Bestrahlung | |
| Plattenepithel-Karzinom | 103 75,2% | 115 82,1% | |
| Adenokarzinom | 16 11,7% | 11 7,9% | |
| Adenosquamös | 18 13,1% | 14 10,0% | |
| Tumorgröße | bis 3 cm | 39 29,3% | 58 42,6% |
| > 3 cm | 94 70,7% | 78 57,4% | |
| unbekannt | 4 | 4 | |
| Risikofaktoren | L1, >2/3 Invasion | 60 43,8% | 69 49,3% |
| L1, >1/3 Invasion, ab 2cm | 28 20,4% | 37 26,4% | |
| Lo, >1/3 Invasion, ab 4cm | 23 16,8% | 13 9,3% | |
| L- >2/3 Invasion, ab 4cm | 25 18,3% | 21 15,0% | |
| L1, <1/3 Invasion, 5cm | 1 0,7% | 0 0,0% | |
| Ereignis | postoperative Bestrahlung | keine Bestrahlung |
| Rezidive | 24 | 43 |
| vaginales Rezidiv | 2 | 8 |
| Beckenrezidiv | 16 | 19 |
| Becken + Vagina | 1 | 2 |
| Fernmetastasen | 4 | 12 |
| unbekannt | 1 | 2 |
| RFS | 113 82,5% | 97 69,3% |
| Sterbefälle | 27 19,7% | 40 28,6% |
| Histologie | postoperative Bestrahlung | keine Bestrahlung |
| Adenocarcinoma | 0 | 4 - 36,4% |
| Adenosquamous | 3 - 16,7% | 7 - 50% |
| Squamous | 21 - 20,4% | 32 - 27,8% |
A phase III randomized trial of postoperative pelvic irradiation in stage Ib cervical carcinoma with poor prognostic features: follow-up of a gynecologic oncology group study.
IJROBP 65(2006):169–176
2.) Sedlis A, Bundy BN, Rotman MZ, et al.:
A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenopathy: A Gynecological Oncology Group study.
Gynecol Oncol 73(1999):177–183
