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AGO-Uterus-12: Sentinell Prospective, randomized and multicenter study for investigation of validity of the sentinel lymph node concept in patients with cervical Cancer < 2 cm Studienleiter: Prof. Schneider, Gynäkologie, Charité
GOG 206 Cervix - Stage IB1. Sentinal lymph node biopsy.(ongoing, 2003-)
LACC Nach laparoskopischer (TLRH) oder roboterassistierter radikaler Hysterektomie (TRRH) bei Zervixkarzinomen im Stadium FIGO I war das DFS, PFS und OS schlechter als nach einer abdominellen radikalen Hysterektomie (TARH)! Rekrutierung abgebrochen.
Strahlentherapie RTOG 97-07Concomitant Parametrial Boost 9707 Phase I/II Study of Concomitant Parametrial Boost Radiation Therapy for Locally Advanced Cervical Cancer Terminated I/II
RTOG 96-13 Extended Field Radiation - Para-Aortic Node Dissection 9613 A Phase II Study of Extended Field Radiation Following Therapeutic Para-Aortic Node Dissection for Patients with Carcinoma of the Uterine Cervix with Para-Aortic Nodal Metastases Terminated Phase II
Radio - Chemotherapie primäre Radio - Chemotherapie GOG 9804 GOG 85 GOG 120
GOG 191 GOG 165 GOG 85 RTOG 01-28
postoperative Radio-Chemotherapie RTOG 0724/GOG-0724
praeoperative Radio - Chemotherapie GOG 123 praeoperative Radio(-Chemo)-Therapie RT v. RT + Cisplatin vor OP
GYNECO 02 praeoperative RCh: CR +- OP  
postoperative Radiotherapie GOG 92 postoperative Radiotherapie
PARCER Postoperative Adjuvant Radiation in Cervical Cancer Eine postoperative Bestrahlung mit IG-IMRT hat weniger Nebenwirkungen und gleich gute Ergebnisse wie eine konventionelle Bestrahlung.
praeoperative Chemotherapie EORTC 55994 Randomized phase III study of neoadjuvant chemotherapy followed by surgery vs. concomitant radiotherapy and chemotherapy in FIGO Ib2, IIa > 4 cm or IIb cervical cancer. Trial Coordinators: A Colombo - Lecco Italien, S Greggi - Neapel, G Kenter - Leiden, F Landoni - Milano
ANZGOG 0902/GOG-0274/RTOG 1174, OUTBACK Trial A Phase III Trial of Adjuvant Chemotherapy as Primary Treatment for Locally Advanced Cervical Cancer Compared to Chemoradiation Alone Open III
medikamentöse Therapie AGO - Zervix 1 Pazopanib - Studie GOG 0227-C
GOG 240 (4) GOG 204 GOG 179
GOG 169 GOG 149 GOG 110 GOG 43
GOG 171 Praekanzerosen Expression of the MN Protein in Atypical Glandular Cells of Undetermined Significance (AGUS or AGCUS) as a Potential Diagnostic Biomarker of Cervical Dysplasia/Neoplasia
GOG 154 HIV HUMAN IMMUNODEFICIENCY VIRUS (HIV) TESTING IN PATIENTS WITH INVASIVE CERVICAL CANCER
GOG 47 Adriamycin + Cyclophosphamid + Cisplatin besser als Adriamycin + Cyclophosphamid
RTOG 92-10 (1)  
RTOG 0116 (2)  
Diagnostik MR-Lymphographie GOG-233 (5,6) Preoperative ferumoxtran-10 enhanced MRI to evaluate retroperitoneal lymph node metastasis in advanced cervical cancer:.

Teil von

 Zervix - Karzinom Gynäkologische Onkologie Onkologie Uterus
Quellen 1.) Grigsby PW, Heydon K, Mutch DG, Kim RY, Eifel P:
Longterm follow-up of RTOG 92-10: cervical cancer with positive para-aortic lymph nodes.
IJROBP 51(2001):982–987

2.) Small J, Winter K, Levenback C, et al.:
Extended-field irradiation and intracavitary brachytherapy combined with cisplatin chemotherapy for cervical cancer with positive para-aortic or high common iliac lymph nodes: Results of ARM 1 of RTOG 0116.
IJROBP 68(2007):1081–1087

3.) Walker JL, Morrison A, DiSilvestro P, Von GV:
A phase I/II study of extended field radiation therapy with concomitant paclitaxel and cisplatin chemotherapy in patients with cervical carcinoma metastatic to the para-aortic lymph nodes: A Gynecologic Oncology Group study.
Gynecol Oncol 112(2009):78–84

4.) Tewari K, et al.:
GOG-240 Phase III randomized clinical trial of cisplatin plus paclitaxel vs the non-platinum chemotherapy doublet of topotecan plus paclitaxel in women with recurrent, persistent, or advanced cervical carcinoma: a Gynecologic Oncology Group study.
Gynecol Oncol: 2012. (Abstract) (In Press)

5.) Gold M, et al.:
MRI prior to systematic lymphadenectomy in patients with locally advanced cervical cancer.
J Clin Oncol 29(2011):15s (ASCO #5042): 342s (Abstract)

6.) Atri M, et al.:
Utility of preoperative ferumoxtran-10 enhanced MRI to evaluate retroperitoneal lymph node metastasis in advanced cervical cancer: Results of ACRIN 6671/GOG 0233.
J Clin Oncol 29(2011):15s (ASCO #5035): 340s, (Abstract)

7.) Obermair A, Gebski V, Frumovitz M, et al.:
A phase III randomized clinical trial comparing laparoscopic or robotic radical hysterectomy with abdominal radical hysterectomy in patients with early stage cervical cancer.
J Minim Invasive Gynecol 2008;15:584–588

8.) Landoni F, Maneo A, Colombo A, et al.:
Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer.
Lancet 1997;350:535–540

9.) Chopra S, et al.:
Late Toxicity After Adjuvant Conventional Radiation Versus Image-Guided Intensity-Modulated Radiotherapy for Cervical Cancer (PARCER): A Randomized Controlled Trial.
J Clin Oncol 2021;39:3682-3692
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