zurück Home | α / β - Model | ||
allgemeines | Die Dosis-Wirkungs-Beziehung von Strahlen lässt sich mit einem 2-Komponenten-Model beschreiben. | ||
α | ist ein linearer Faktor | ||
β | ist ein quadratischer Faktor | ||
Formel | d: Strahlendosis / Gy | ||
α/β | Gewebe- und Zell-spezifischer Faktor, wird empirisch ermittelt | ||
Berechnung biologisch äquivalenter Dosen bei unterschiedlicher Einzeldosis | |||
TCP | Tumor Control Probability | ||
Teil von |
Strahlenbiologie | Radioonkologie | Onkologie |
Quellen |
1.) Joiner MC, Van der Kogel AJ: The linear-quadratic approach to fractionation and calculation of isoeffect relationships. In: Steel GG (ed): Basic clinical radiobiology. Oxford University Press, New York 1997, S.: 106–112 2.) Fowler JF: The linear-quadratic formula and progress in fractionated radiotherapy. Br J Radiol 62(1989):679-694. 3.) Thames HD, Bentzen SM, Turesson I, et al.: Time-dose factors in radiotherapy: A review of the human data. Radiother Oncol 19(1990):219-235. 4.) Barendsen GW: Dose fractionation, dose rate and iso-effect relationships for normal tissue response. Int J Radiation Oncology Biology & Physics 8, 1981/1997, 1982. 5.)Dale RG: The application of the linear-quadratic model to fractionated radiotherapy when there is incomplete normal tissue recovery between fractions, and possible implications for treatments involving multiple fractions per day. Brit J Radiology 59(1990): 919-927 6.) Dale RG: The use of small fraction numbers in high dose rate gynaecological afterloading: some radiobiological considerations. Brit J Radiology 63(1990): 290294 7.) Fowler JF: Dose-rate effects in normal tissues. In: Mould RF (Ed): Brachytherapy 2, S26-40, Nucletron:Leersum, 1989. 8.) Fowler JF: The radiobiology of brachytherapy. In: Martinez AA, Orton CG & Mould RF (Eds): Brachytherapy HDR and LDR, S121-137, Nucletron:Columbia, 1990. 9.) Kelland LR, Steel GG: Recovery from radiation damage in human squamous carcinoma of the cervix. Int J Radiation Biology 55(1989):119-127 10.) Steel GG, Deacon JM, Duchesne GM, Horwich A, Kelland LR, Peacock JM: Review: The dose rate effect in human tumour cells. Radiother Oncol 9(1987):299-310 11.) Stitt JA, Fowler JF, Thomadsen B, Buchler DA, Shahabi S, Paliwal BP, Kinsella TJ: High dose rate brachytherapy for cancer of the uterine cervix: the Madison System. 1: Clinical & radiobiological considerations. Int J Radiation Oncology Biology Physics 1991. 12.) Thames HD, Hendry JH: Fractionation in radiotherapy. Taylor & Francis:London, 1987. 13.) Thames HD, Bentzen SM, Turesson I, Overgaard M, van den Bogaert W: Time-dose factors in radiotherapy: a review of human data. Radiother Oncol 19(1990):219-235 14.) Warmelink C, Ezzell G, Orton C: Use of a time-dosefractionation model to design high dose-rate fractionation schemes. In: Mould RF (Ed): Brachytherapy 2, S41-48, Nucletron: Leersum 1989. | ||
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