zurück Home α / β - Model  
allgemeines Die Dosis-Wirkungs-Beziehung von Strahlen lässt sich mit einem 2-Komponenten-Model beschreiben.
α ist ein linearer Faktor
β ist ein quadratischer Faktor
Formel a/b - Formeld: Strahlendosis / Gy
α/β Gewebe- und Zell-spezifischer Faktor, wird empirisch ermittelt
Berechnung biologisch äquivalenter Dosen bei unterschiedlicher Einzeldosis
TCP Tumor Control Probability

Teil von

Strahlenbiologie Radioonkologie Onkologie

Teil von

Strahlenbiologie Radioonkologie Onkologie
Quellen 1.) Joiner MC, Van der Kogel AJ:
The linear-quadratic approach to fractionation and calculation of isoeffect relationships.
In: Steel GG (ed):
Basic clinical radiobiology.
Oxford University Press, New York 1997, S.: 106–112

2.) Fowler JF:
The linear-quadratic formula and progress in fractionated radiotherapy.
Br J Radiol 62(1989):679-694.

3.) Thames HD, Bentzen SM, Turesson I, et al.:
Time-dose factors in radiotherapy: A review of the human data.
Radiother Oncol 19(1990):219-235.

4.) Barendsen GW:
Dose fractionation, dose rate and iso-effect relationships for normal tissue response.
Int J Radiation Oncology Biology & Physics 8, 1981/1997, 1982.

5.)Dale RG:
The application of the linear-quadratic model to fractionated radiotherapy when there is incomplete normal tissue recovery between fractions, and possible implications for treatments involving multiple fractions per day.
Brit J Radiology 59(1990): 919-927

6.) Dale RG:
The use of small fraction numbers in high dose rate gynaecological afterloading: some radiobiological considerations.
Brit J Radiology 63(1990): 290­294

7.) Fowler JF:
Dose-rate effects in normal tissues.
In: Mould RF (Ed): Brachytherapy 2, S26-40, Nucletron:Leersum, 1989.

8.) Fowler JF:
The radiobiology of brachytherapy.
In: Martinez AA, Orton CG & Mould RF (Eds): Brachytherapy HDR and LDR, S121-137, Nucletron:Columbia, 1990.

9.) Kelland LR, Steel GG:
Recovery from radiation damage in human squamous carcinoma of the cervix.
Int J Radiation Biology 55(1989):119-127

10.) Steel GG, Deacon JM, Duchesne GM, Horwich A, Kelland LR, Peacock JM:
Review: The dose rate effect in human tumour cells.
Radiother Oncol 9(1987):299-310

11.) Stitt JA, Fowler JF, Thomadsen B, Buchler DA, Shahabi S, Paliwal BP, Kinsella TJ:
High dose rate brachytherapy for cancer of the uterine cervix: the Madison System.
1: Clinical & radiobiological considerations.
Int J Radiation Oncology Biology Physics 1991.

12.) Thames HD, Hendry JH:
Fractionation in radiotherapy.
Taylor & Francis:London, 1987.

13.) Thames HD, Bentzen SM, Turesson I, Overgaard M, van den Bogaert W:
Time-dose factors in radiotherapy: a review of human data.
Radiother Oncol 19(1990):219-235

14.) Warmelink C, Ezzell G, Orton C:
Use of a time-dose­fractionation model to design high dose-rate fractionation schemes.
In: Mould RF (Ed): Brachytherapy 2, S41-48, Nucletron: Leersum 1989.

blauer Punkt  

Impressum                         Zuletzt geändert am 27.07.2025 18:12