zurück α / β - Model  
allgemeines Die Dosis-Wirkungs-Beziehung von Strahlen lässt sich mit einem 2-Komponenten-Model beschreiben.
α ist ein linearer Faktor
β ist ein quadratischer Faktor
Formel a/b - Formeld: Strahlendosis / Gy
α/β Gewebe- und Zell-spezifischer Faktor, wird empierisch ermittelt
Berechnung biologisch äquivalenter Dosen bei unterschiedlicher Einzeldosis
TCP Tumor Control Probability
Quellen 1.) Joiner MC, Van der Kogel AJ:
The linear-quadratic approach to fractionation and calculation of isoeffect relationships.
In: Steel GG (ed):
Basic clinical radiobiology.
Oxford University Press, New York 1997, S.: 106–112

2.) Fowler JF:
The linear-quadratic formula and progress in fractionated radiotherapy.
Br J Radiol 62(1989):679-694.

3.) Thames HD, Bentzen SM, Turesson I, et al.:
Time-dose factors in radiotherapy: A review of the human data.
Radiother Oncol 19(1990):219-235.

4.) Barendsen GW:
Dose fractionation, dose rate and iso-effect relationships for normal tissue response.
Int J Radiation Oncology Biology & Physics 8, 1981/1997, 1982.

5.)Dale RG:
The application of the linear-quadratic model to fractionated radiotherapy when there is incomplete normal tissue recovery between fractions, and possible implications for treatments involving multiple fractions per day.
Brit J Radiology 59(1990): 919-927

6.) Dale RG:
The use of small fraction numbers in high dose rate gynaecological afterloading: some radiobiological considerations.
Brit J Radiology 63(1990): 290­294

7.) Fowler JF:
Dose-rate effects in normal tissues.
In: Mould RF (Ed): Brachytherapy 2, S26-40, Nucletron:Leersum, 1989.

8.) Fowler JF:
The radiobiology of brachytherapy.
In: Martinez AA, Orton CG & Mould RF (Eds): Brachytherapy HDR and LDR, S121-137, Nucletron:Columbia, 1990.

9.) Kelland LR, Steel GG:
Recovery from radiation damage in human squamous carcinoma of the cervix.
Int J Radiation Biology 55(1989):119-127

10.) Steel GG, Deacon JM, Duchesne GM, Horwich A, Kelland LR, Peacock JM:
Review: The dose rate effect in human tumour cells.
Radiother Oncol 9(1987):299-310

11.) Stitt JA, Fowler JF, Thomadsen B, Buchler DA, Shahabi S, Paliwal BP, Kinsella TJ:
High dose rate brachytherapy for cancer of the uterine cervix: the Madison System.
1: Clinical & radiobiological considerations.
Int J Radiation Oncology Biology Physics 1991.

12.) Thames HD, Hendry JH:
Fractionation in radiotherapy.
Taylor & Francis:London, 1987.

13.) Thames HD, Bentzen SM, Turesson I, Overgaard M, van den Bogaert W:
Time-dose factors in radiotherapy: a review of human data.
Radiother Oncol 19(1990):219-235

14.) Warmelink C, Ezzell G, Orton C:
Use of a time-dose­fractionation model to design high dose-rate fractionation schemes.
In: Mould RF (Ed): Brachytherapy 2, S41-48, Nucletron: Leersum 1989.

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