Allgemeines
Operation
blasenerhaltende Therapie
| Study (ref) | No. of patients | Technique | 2a-OS | 3a-OS | 5a-OS | 10a-OS | 3a-DSS | 5a-DSS | 10a-DSS | 2a-Blasenerhalt | 3a-Blasenerhalt | 5a-Blasenerhalt | 10a-Blasenerhalt |
| Efstathiou et al (3) | 190 | Conventional | - | - | 52% | 35% | - | 64% | 59% | - | - | 80% | - |
| Rödel et al (4) | 326 | Conventional | - | - | 45% | 29% | - | 56% | 42% | - | - | - | 64% |
| Mak et al (5) | 468 | Conventional | - | - | 57% | 36% | - | 71% | 65% | - | - | 80% | - |
| Huddart et al (6) | 108-Standard whole-bladder RT arm | 3DCRT | - | - | 38% | - | - | - | - | 89,8% | - | - | - |
| 111-Reduced high-dose volume RT arm | - | - | 44% | - | - | - | - | 88,3% | - | - | - | ||
| Chung et al (7) | 340 | Conventional | - | - | 32% | 19% | - | 42% | 35% | - | - | 87% | - |
| Baxter et al (8) | 50 | 3DCRT | - | - | 30% | 17% | - | 31% | 27% | - | - | 60% | - |
| Lee et al (9) | 70 | 3DCRT followed by IMRT for tumor bed boost | - | - | 50,8 | - | - | 67,3% | - | - | - | 61,7% | - |
| Hoskin et al (10) | 163-RT - alone arm | 3DCRT | - | 46% | - | - | 43% | - | - | - | - | - | - |
| 164-RT + CON arm | - | 59% | - | - | 54 | - | - | - | - | - | - | ||
| Turgeon et al (11) | 24 | IMRT | - | 61% | - | - | 71% | - | - | - | 75% | - | - |
| Meijer et al (12) | 20 | Adaptive RT | 50% | - | - | - | - | - | - | 90% | - | - | - |
| Present study (13) | 44 | Adaptive RT | - | 67% | - | - | 73% | - | - | - | 83% | - | - |
Quellen
Improved local control of invasive bladder cancer by concurrent cisplatin and preoperative or definitive radiation.
JCO 14(1996):2901-7
2.) Ploussard G, et al.:
Critical analysis of bladder sparing with trimodal therapy in muscle-invasive bladder cancer: a systematic review.
Eur Urol 2014;66:120-37.doi: 10.1016/j.eururo.2014.02.038
3.) Efstathiou JA, Spiegel DY, Shipley WU, et al.:
Long-term outcomes of selective bladder preservation by combined-modality therapy for invasive bladder cancer: The MGH experience.
Eur Urol 2012;61:705-74
4.) Rödel C, Grabenbauer GG, Ku¨hn R, et al.:
Combined-modality treatment and selective organ preservation in invasive bladder cancer: Long-term results.
J Clin Oncol 2002;20:3061-3071
5.) Mak RH, Hunt D, Shipley WU, et al.:
Long-term outcomes in patients with muscle-invasive bladder cancer after selective bladder-preserving combined-modality therapy: A pooled analysis of Radiation Therapy Oncology Group protocols 8802, 8903, 9506, 9706, 9906, and 0233.
J Clin Oncol 2014;32:3801-3809
6.) Huddart RA, Hall E, Hussain SA, et al.:
Randomized non inferiority trial of reduced high-dose volume versus standard volume radiation therapy for muscle-invasive bladder cancer: Results of the BC2001 trial (CRUK/01/004).
Int J Radiat Oncol Biol Phys 206;87:261-269
7.) Chung PWM, Bristow RG, Milosevic MF, et al.:
Long-term outcome of radiation-based conservation therapy for invasive bladder cancer.
Urol Oncol 2007;25:303-309
8.) Baxter E, Dennis K, Kollmannsberger C, et al.:
Radical trimodality therapy for patients with locally advanced bladder cancer: The British Columbia Cancer Agency experience.
Urol Oncol 2015;33:66.e6-66,e19
9.) Lee C, Yang K, Ko H, et al.:
Trimodality bladder-sparing approach without neoadjuvant chemotherapy for node-negative localized muscle-invasive urinary bladder cancer resulted in comparable cystectomy-free survival.
Radiation Oncology 2014;9:1-8
10. Hoskin PJ, Rojas AM, Bentzen SM, et al.:
Radiotherapy with concurrent carbogen and nicotinamide in bladder carcinoma.
J Clin Oncol 2010;28:4912-4918
11. Turgeon G-A, Souhami L, Cury FL, et al.:
Hypofractionated intensity modulated radiation therapy in combined modality treatment for bladder preservation in elderly patients with invasive bladder cancer.
Int J Radiat Oncol Biol Phys 2014;88:326-331
12. Meijer GJ, Van Der Toorn PP, Bal M, et al.:
High precision bladder cancer irradiation by integrating a library planning procedure of 6 prospectively generated SIB IMRT plans with image guidance using lipiodol markers.
Radiother Oncol 2012;105:174-179
13.) Murthy V, et al.:
Clinical Outcomes With Dose-Escalated Adaptive Radiation Therapy for Urinary Bladder Cancer: A Prospective Study.
Int J Radiation Oncol Biol Phys 2016;94,60-66
http://dx.doi.org/10.1016/j.ijrobp.2015.09.010
14.) James ND, Hussain SA, Hall E et al.:
Radiotherapy with or without chemotherapy in muscle-invasive bladder cancer.
N Engl J Med 2012;366:1477–1488
15.) Weiss C, Wittlinger M, Engehausen DG et al.:
Management of superficial recurrences in an irradiated bladder after combined- modality organ-preserving therapy.
Int J Radiat Oncol Biol Phys 2008;70:1502–1506
16.) Zietman AL, Grocela J, Zehr E et al.:
Selective bladder conservation using transurethral resection, chemotherapy, and radiation: management and consequences of Ta, T1, and Tis recurrence within the retained bladder.
Urology 2001;58:380–385
17.) Gray PJ, Fedewa SA, Shipley WU et al.:
Use of potentially curative therapies for muscle-invasive bladder cancer in the United States: results from the national cancer data base.
Eur Urol 2006;63:823–829
18.) Efstathiou JA, Spiegel DY, Shipley WU et al.:
Long-term outcomes of selective bladder preservation by combined-modality therapy for invasive bladder cancer: the MGH experience.
Eur Urol 2012;61:705–74
19.) Shipley WU, Kaufman DS, Zehr E et al.:
Selective bladder preservation by combined modality protocol treatment: long-term outcomes of 190 patients with invasive bladder cancer.
Urology 2002;60:62–67
20.) Krause FS, Walter B, Ott OJ et al.:
15-year survival rates after transurethral resection and radiochemotherapy or radiation in bladder cancer treatment.
Anticancer Res 2004;31:985–990
21.) Dunst J, Sauer R, Schrott KM, et al.:
Organ-sparing treatment of advanced bladder cancer: a 10-year experience.
Int J Radiat Oncol Biol Phys 1994;30:261–266
