modifiziert nach (2)
| maligne | epithelial | HCC, Hepatozelluläres CA | |
| MTHCC | Macrotrabecular hepatocellular carcinoma | TP53 Mutation, FGF19 - Amplifikation, Überexpression of Proangiogenetischer Proteine (ESM1, Angiopoietin, EGF)(3) | AFP hoch, aggressives Verhalten, hohe Rezidivrate, geringeres Survival |
| cholangiozelluläres CA | |||
| Hepatoblastom | |||
| Fibrolammelläres Karzinom | |||
| Spindelzellig differenziertes HCC | |||
| Plattenepithelkarzinom | |||
| Zystadenokarzinom | |||
| kombiniertes HCC/CCC | |||
| mesenchymal | Angiosarkom | ||
| Fibrosarkom | |||
| Malignes fibröses Histiozytom | |||
| Leiomyosarkom | |||
| Malignes Schwannom | |||
| Rhabdomyosarkom | |||
| Malignes epitheloides Hämangioendotheliom | |||
| benigne | Adenome | Leberzell - Adenome |
| Gallengangs - Adenome | ||
| mesenchymal | Hämangiome | |
| PECom, Perivaskuläre epithelioide Zell-Tumore | ||
| Angiomyolipom -Lymphangiom | ||
| Infantiles Hämangioendotheliom |
(4,5)
| Subtyp | frequency | Prognosis | Key histological features |
| Steatohepatitic (Sh-ST) | 5-20% | Comparable | Lesion shows histological signs Of steatohepatitis |
| Clear cell (Cc-ST) | 3-7% | Improved | > 80% Of the tumor shows Clear cell morphology due to an accumulation of glycogen A minor degree Of steatosis is acceptable |
| Macrotrabecular massive (Mt-ST) | 5% | Inferior | Macrotrabecular growth pattem in of the tumor Vascular invasion is common |
| Scirrhous (Scirr-ST) | 4% | Variable (consensus missing) | > 50% of the tumor shows dense fibrosis |
| Chromophobe (Chr-ST) | 3% | Comparable | Almost Clear cytoplasm With mainly bland tumor nuclei Focal areas Of more striking nuclear atypia |
| Fibrolamellar (Fib-ST) | 1% | Comparable to that of HCC in non-cirrhotic livers | Large eosinophilic tumor Cells With prominent nucleoli Dense intratumoral fibrosis |
| Not otherwise specified (Nos-ST) | All not specified | Referenz | Histology does not match the criteria for any other subtype |
Teil von
Tumoren der Leber.
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2.) Ishak KG, Anthony PP, Sabin LH:
WHO Histological typing of tumours of the liver.
2. Auflage Springer 1994
3.) Ziol M, Poté N, Amaddeo G, et al.:
Macrotrabecular-massive hepatocellular carcinoma: a distinctive histological subtype with clinical relevance.
Hepatology 2018;68:103–112
4.) Nagtegaal ID, Odze RD, Klimstra D et al.:
The 2019 WHO classification of tumours of the digestive system.
Histopathology 2020;76(2):182-8
5.) Torbenson MN, Ng IOL, Park YN, Roncalli M, Sakamato M
WHO classification of digestive systems tumors.
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