Mamma - Karzinom: Brusterhaltende Therapie
| Studie | % Brustrezidive / 5 Jahre | |
| ohne RT | mit RT | |
| NSABP B-06 (1976–1984)(1) | 39.2 | 14.3 |
| Uppsala-Oerebro (1981-1988)) | 24 | 8,5 |
| St. George’s London (1981–1990) | 35 | 13 |
| CRC, UK (1981–1990) | 40,6 | 19,7 |
| Ontario COG (1984–1989) | 35 | 11 |
| SCTBG (1985–1991) | 24,5 | 5,8 |
| INT Milan 3 (1987–1989) | 23,5 | 5,8 |
| NSABP B-21 (1989–1998) | 16,5 | 2,8 |
| Swedish BCG 91-RT (1991–1997) | 14 | 4 |
| Holli et al. (1990–1995) | 14,1 | 6,3 |
| Winzer et al. für GBSG (1991–1998) | 15,7 | 3,7 |
| Fyles et al. (1992–2000) | 7,7 | 0,6 |
| CALGB C9343 study (1994–1999) | 4 | 1 |
| ABCSG study 8 (1996–2004) | 5,1 | 0,4 |
| BASO II | 16 | nn |
| Milan I | Halsted versus Quadrantektomie und RT | Rezidivrate und Überleben gleich(2,3) | 1973-1980 | <2cm, cNo. Ab 1976 12 Monate CMF bei pN+ |
| Milan II | Quadrantektomie + RT 50Gy + 10Gy Boost versus Lumpektomie + RT 45Gy + AL | Rezidivrate und Überleben gleich | 1985-1987 | 705 Pat. |
| Milan III | Quadrantektomie mit und ohne RT | 1988-1989 | 601 Pat. |
Eight-year results of a randomized trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer.
NEJM 320(1989):822–828
2.) Veronesi U, Saccozzi R, Del Vecchio M,et al.:
Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast.
N Engl J Med 1981;305:6-11
3.) Veronesi U, Banfi A, Del Vecchio M, et al.:
Comparison of Halsted mastectomy with quadrantectomy, axillary dissection, and radiotherapy in early breast cancer: long-term results.
Eur J Cancer Clin Oncol 1986;22:1085-1089
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