NSCLC: Studien
primäre RT
| ARO 97-1 | Continuous hyperfractionated accelerated radiotherapy. CHARTWEL = CHART weekend less |
| RTOG 73-02 | Strahlentherapie beim fortgeschrittenen NSCLC: 30Gy, 40Gy, 40Gy split course |
| RTOG 93-11 | Phase I-II radiation dose-escalation study in patients with inoperable non-small-cell lung cancer (13). |
| RTOG 09-15 | Comparing 1x 34 Gy versus 4 x 12 Gy for Medically Inoperable Patients With Stage I Peripheral NSCLC |
| LUSTRE | Stereotactic vs Hypofractionated Radiotherapy for Inoperable Stage I NSCLC. SBRT 48 Gy 4 frx peripheral NSCLC or 60 Gy 8 frx central NSCLC vs CRT 60 Gy 15 frx. |
postoperative RT
| ARO 2014-2, PORTAF | Postoperative Strahlentherapie des nicht - kleinzelligen Lungenkarzinoms: Akzelerierte vs. konventionelle Fraktionierung. | Phase III. | Baumann, Dresden. |
ZNS - RT
| NVALT-11/DLCRG-02 (14) | Prophylactic Cranial Irradiation Versus Observation in Radically Treated Stage III Non-Small-Cell Lung Cancer. | Phase III. | Baumann, Dresden. |
Chemotherapie
Tax301 (12)
RCH
GILT |
German Intergroup Lung Cancer Trial. Simultane Radiochemotherapie mit Navelbine oral +- Konsolidierung |
| RTOG 1308 | Phase III Randomized Trial Comparing Overall Survival After Photon Versus Proton Chemoradiotherapy for Inoperable Stage II-IIIB NSCLC: geplant |
| Conrad | Eine simultane Radiochemotherapie mit Vinorelbin-Carboplatin verbessert das Überleben beim NSCLC im Stadium IIIb gegenüber einer alleinigen Chemotherapie signifikant! |
| PET-Plan | Optimierung der Strahlentherapieplanung von Patienten mit inoperablen lokal fortgeschrittenen nicht - kleinzelligen Bronchialkarzinomen mittels FDG-PET. |
OP - RCH
RTOG 9705 |
Postoperative Radiochemotherapie mit Paclitaxel - Carboplatin |
CH - Immun - OP - Immun
| SAKK 16/14 (14) | 3x Cisplatin 100 mg/qm + Docetaxel 85 mg/qm, q22. 2x Durvalumab 750 mg q15. OP. Dann 1 Jahr Durvalumab. |
RCH - OP
| SWOG8805 (1) | Concurrent cisplatin/etoposide plus chest radiotherapy followed by surgery for stages IIIA (N2) and IIIB non–small-cell lung cancer. | |||
GLCCG (2) | Cisplatin/etoposide (PE) followed by twice-daily chemoradiation (hfRT/CT) versus PE alone before surgery in stage III non-small cell lung cancer (NSCLC). | |||
RTOG93-09 (4) |
Concurrent chemotherapy plus radiotherapy and CT/RT followed by surgical resection for stage IIIA(pN2) NSCLC. | |||
| Eine praeoperative Radiochemotherapie erzielt häufiger ein Downstaging als eine Chemotherapie allein. | ||||
| ARO 2004-4 | NSCLC Stad IIIA/IIIB: Prospektiv randomisierte Studie einer Boost-Bestrahlung versus Operation nach Induktionschemotherapie mit Cisplatin/Taxol und neoadjuvanter hyperfraktioniert akzelerierter Radiochemotherapie | Phase III | Eberhardt, Essen | 71/500 rekrutiert |
CH - OP oder RT
| Bevacizumab, Avastin® | CALGB-8433 | RTOG 8808 | |||
| Erlotinib, Tarceva® | BR.21 | TRUST | SATURN | EURTAG | |
| TITAN | OPTIMAL | Innovations | |||
| Gefitinib, Iressa® | INTEREST | IPASS | V-15-32 | Cetuximab | RTOG 0324 |
| Vadimezan | ATTRACT-1 | ATTRACT-2 | |||
| Onartuzumab | MetLung |
| Thalidomid | ECOG 3598 | |
| Nivolumab | CheckMate-17 | Mit Nivolumab wurde die Überlebenszeit bei einer second-line Therapie fortgeschrittener Plattenepithelkarzinome des Bronchus gegenüber Docetaxel von 6 auf 9,2 Monate verlängert! Die Rate schwerer Nebenwirkungen konnte von 55% auf 7% gesenkt werden. |
| CheckMate-057 | Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer. | |
| FORCE | AIO-Studie: FOstering efficacy of anti - PD-1-treatment. Nivolumab plus Radiotherapy in advanced NSCLC | |
Pembrolizumab |
KEYNOTE-001 | Phase 1 - Studie mit Pembrolizumab bei fortgeschrittenem NSCLC |
| KEYNOTE-010 | Pembrolizumab erzielt in der Second - Line - Therapie des fortgeschrittenen NSCLC ein signifikant höheres Gesamtüberleben als Docetaxel! | |
| Atezolizumab | OAK | Atezolizumab erzielt in der Second - Line - Therapie des fortgeschrittenen NSCLC ein signifikant höheres Gesamtüberleben bei weniger Nebenwirkungen als Docetaxel! |
| POPLAR | Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer | |
| Ipilimumab | Yale-Studie | Ipilimumab in Combination With Paclitaxel and Carboplatin As First-Line Treatment in Stage IIIB/IV Non–Small-Cell Lung Cancer |
| Durvalumab | PACIFIC | Der PD-L1-IH Durvalumab verlängert signifikant das progressionsfreie Überleben mit NSCLC im Stadium 3 nach einer platinhaltigen Radiochemotherapie! |
Vakzine
| Mage-A3 | MARGRIT |
| MUC1 | START |
Teil von
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